GDC-0879

Product Name: GDC-0879
CAS No.: 905281-76-7
Chemical Name: GDC-0879
Synonyms: CS-187;GDC-0879;GDC 0849;AR-00341677;GDC0879;GDC 0879;GDC-0879 >=98% (HPLC);GDC-0879 ISO 9001：2015 REACH;2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol;2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime;(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
CBNumber: CB12473919
Molecular Formula: C19H18N4O2
Formula Weight: 334.37
MOL File: 905281-76-7.mol

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GDC-0879 Property

Density: 1.37
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥16.7 mg/mL in DMSO
form: solid
Stability:: Hygroscopic

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1953
Product name: GDC-0879
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $131
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1953
Product name: GDC-0879
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $530
Updated: 2024/03/01

Cayman Chemical

Product number: 16993
Product name: GDC 0879
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16993
Product name: GDC 0879
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 16993
Product name: GDC 0879
Purity: ≥95%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

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GDC-0879 Chemical Properties,Usage,Production

Uses

GDC 0879 is a potent B-Raf inhibitor.

Definition

ChEBI: GDC-0879 is a member of the class of pyrazoles that is 1-(2-hydroxyethyl)pyrazole carrying additional 4-pyridyl and 1-(hydroxyimino)indan-5-yl substituents at positions 3 and 4 respectively. It has a role as a B-Raf inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of pyridines, a member of indanes, a ketoxime and a primary alcohol.

Biological Activity

gdc-0879 is synthsized as a potent and selective b-raf inhibitor. the raf/mitogen-activated protein kinase kinase (mek)/extracellular signal-regulated kinase signaling pathway is reported to be involved in cellular responses, which is relevant to tumorigenesis.

in vitro

gdc-0879 is a b-raf inhibitor against various in vitro and cell-based assays, such as a375 melanoma and colo205 colorectal carcinoma cell lines, both of which are v600e b-raf mutant. when screened against a panel of 140 kinases at its efficaciou dose, gdc-0879 showed expected activity only against c-raf [1].

in vivo

in mice treated by gdc-0879, both cell line-and patient-derived brafv600e tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant kras-expressing tumors. moreover, it was found that the responsiveness of brafv600e melanoma cells to gdc-0879 could be dramatically altered by pharmacologic and genetic modulation of phosphatidylinositol 3-kinase pathway activity [2].

IC 50

0.13 nm against purified b-raf v600e enzyme; a cellular perk ic50 of 63 nm in the malme-3m cell line

storage

Store at -20°C

References

[1] wong h, belvin m, herter s, hoeflich kp, murray lj, wong l, choo ef. pharmacodynamics of 2-[4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridine-4-yl)-1h-pyrazol-1-yl]ethan-1-ol (gdc-0879), a potent and selective b-raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. j pharmacol exp ther. 2009 apr;329(1):360-7.
[2] hoeflich kp, herter s, tien j, wong l, berry l, chan j, o'brien c, modrusan z, seshagiri s, lackner m, stern h, choo e, murray l, friedman ls, belvin m. antitumor efficacy of the novel raf inhibitor gdc-0879 is predicted by brafv600e mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. cancer res. 2009 apr 1;69(7):3042-51.

GDC-0879 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0879 Suppliers

China 100 The Netherlands 1 United Kingdom 3 United States 20 Global 124

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
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View Lastest Price from GDC-0879 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: GDC-0879 905281-76-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-08

Career Henan Chemical Co

Product: GDC-0879 905281-76-7
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

905281-76-7, GDC-0879Related Search:

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GDC-0879

(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime,GDC-0879

2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime

1H-Inden-1-one, 2,3-dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-, oxiMe

GDC 0849

(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime

2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro -1H-inden-5-yl]-3-pyridin-4-yl-1H-pyrazol-1-yl} ethanol

(Z)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime

(E)-5-(1-(2-Hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol

(E)-2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime

GDC0879;GDC 0879

CS-187

AR-00341677

GDC-0879 >=98% (HPLC)

GDC-0879 ISO 9001：2015 REACH

905281-76-7

MAPK

Inhibitors

Selective inhibitor of protein kinase.